For support throughout the approval process, reach out to Ionis Every Step at 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET
Complete the DAWNZERA Patient Enrollment and Prescription Form and fax it to 1-877-558-0007
If you prescribe the Free Trial Program, the pharmacy typically contacts your patient to schedule the free trial dose shipment within one business day of receiving a valid prescription and patient consent*†
Work with Ionis Every Step™ to navigate patient insurance coverage‡
To learn more about common prior authorization criteria, download the Getting Started Quick Reference Card
Remind patients to answer calls from Ionis Every Step Specialty Pharmacy (1-844-444-4305)
*For eligibility, see terms and conditions at DAWNZERA.com/FreeTrialProgram. May not be billed back to the third-party payer or resold. Participating in the program does not impose an obligation to purchase in the future. Terms and conditions apply. Programs subject to change or discontinue without notice, including in specific states.
†Ionis Every Step internal time-to-shipment analysis based on program operations data. Reflects average time from initial prescription receipt to Free Trial dose shipment scheduling. As of April 13, 2026. (Data on file. Ionis Pharmaceuticals, Inc.)
‡Ionis Every Step offers a comprehensive reauthorization support program, DAWNZERA AuthASSIST, to help you prepare for and navigate the reauthorization process.
For support throughout the approval process, reach out to Ionis Every Step at 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET
DAWNZERA can be prescribed through your EHR or through the DAWNZERA Direct online companion. Reach out to your Account Specialist to gain access to DAWNZERA Direct.
EHR=electronic health record.
DAWNZERA is typically covered under the pharmacy benefit; and similar to other treatments for rare disease, patients may need to meet coverage criteria to receive approval from their insurance plan. Ionis Every Step will confirm your patient’s benefits for DAWNZERA and the criteria required by the insurance plan to request coverage.
Providing all documentation required by the insurance plan to Ionis Every Step early in the process may help avoid unnecessary delays. Ionis Every Step will communicate the required forms and documentation to your office and proactively reach out if more information is needed. For more support with this process, call Ionis Every Step at 1-844-444-4305, Monday to Friday, 8 AM to 8 PM ET.
Once you have collected the required information, you can typically submit to the plan using 1 of 2 methods:
1. Electronically: If this option is available, Ionis Every Step can provide a link to submit
2. Verbally: Your office may need to call the insurance plan and verbally request coverage
Call Ionis Every Step at 1-844-444-4305 with any questions about documentation required by your patient’s insurance plan or how to submit the exception or prior authorization package.
After receiving a denial, your office can initiate the appeals process to request that the insurance plan overturn this decision. The steps below can help you get started:
Click here to download helpful resources, including a Sample Letter of Appeal template and the Navigating the Coverage Process for DAWNZERA Guide. You can also call Ionis Every Step at 1-844-444-4305 for assistance with the appeals process after a coverage denial.
The Ionis Every Step Specialty Pharmacy will call them to set up delivery of DAWNZERA. DAWNZERA will not be shipped until your patient speaks with the pharmacy about potential cost and to setup delivery. Encourage your patient to save the pharmacy’s number (1-844-444-4305) in their phone to help them recognize and answer these calls.
DAWNZERA is contraindicated in patients with a history of serious hypersensitivity reactions, including anaphylaxis, to donidalorsen or any of the excipients in DAWNZERA.
Hypersensitivity reactions, including anaphylaxis, have been reported in patients treated with DAWNZERA. If signs and symptoms of serious hypersensitivity reactions occur, discontinue DAWNZERA and institute appropriate therapy.
Most common adverse reactions (incidence ≥ 5%) are injection site reactions, upper respiratory tract infection, urinary tract infection, and abdominal discomfort.
DAWNZERA (donidalorsen) is indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adult and pediatric patients 12 years of age and older.
Please see full Prescribing Information for DAWNZERA.